Recommendations for a one-size fits all vaccine will increase diseases in all populations.
Vaccination, probably the most controversial word on the planet!
This page is not about ANTI-VAX … Its primary purpose is to inform by collecting solid scientific information and or news articles that provide information mainly neglected by the “main stream media”.
This page is neither built to provoke, abuse or deny. Critical definitely, but also open to receive criticism.
“The better the critic, the more holistic the sense of how own perspectives and tastes fit into the diverse pool of informed opinion of others.”
The contact form is available to anyone. If you think information is incorrect please provide documented conclusive material proving your argument and we will remove the content.
‘The WHO recommendations for vaccines are a one-size fits all and this fact means that these policies will increase diseases in all populations.
They cannot be described as ‘protective health policies’ because they contradict the science of epigenetics; the science showing that individuals are pre-disposed to diseases due to their genetic make-up and the interaction with chemicals in the vaccines. –Judy Wilyman PhD
International Covenant on Civil and Political Rights
Adopted and opened for signature, ratification and accession by General Assembly resolution 2200A (XXI) of 16 December 1966
entry into force 23 March 1976, in accordance with Article 49
No one shall be subjected to torture or to cruel, inhuman or degrading treatment or punishment. In particular, no one shall be subjected without his free consent to medical or scientific experimentation.
Council of Europe – Covid-19 vaccines: ethical, legal and practical considerations
Resolution 2361 (2021)
7.1 with respect to the development of Covid-19 vaccines:
7.1.1 ensure high quality trials that are sound and conducted in an ethical manner in accordance with the relevant provisions of the Convention on human rights and biomedicine (ETS No. 164, Oviedo Convention) and its Additional Protocol concerning Biomedical Research (CETS No. 195), and which progressively include children, pregnant women and nursing mothers;
7.1.2 ensure that regulatory bodies in charge of assessing and authorising vaccines against Covid-19 are independent and protected from political pressure;
7.1.3 ensure that relevant minimum standards of safety, efficacy and quality of vaccines are upheld;
7.1.4 implement effective systems for monitoring the vaccines and their safety following their roll-out to the general population, also with a view to monitoring their long-term effects;
7.1.5 put in place independent vaccine compensation programmes to ensure compensation for undue damage and harm resulting from vaccination;
7.1.6 pay special attention to possible insider trading by pharmaceutical executives, or pharmaceutical companies unduly enriching themselves at public expense, by implementing the recommendations contained in Resolution 2071 (2015) on Public health and the interests of the pharmaceutical industry: how to guarantee the primacy of public health interests?
7.1.7 overcome the barriers and restrictions arising from patents and intellectual property rights, in order to ensure the widespread production and distribution of vaccines in all countries and to all citizens;
7.3 with respect to ensuring high vaccine uptake:
7.3.1 ensure that citizens are informed that the vaccination is NOT mandatory and that no one is politically, socially, or otherwise pressured to get themselves vaccinated, if they do not wish to do so themselves;
7.3.2 ensure that no one is discriminated against for not having been vaccinated, due to possible health risks or not wanting to be vaccinated;
W.H.O Scientists Question Safety Of Vaccines
CAUGHT ON CAMERA: W.H.O Scientists Question Safety Of Vaccines. Shocking footage from inside The W.H.O. Global Vaccine Safety Summit on Dec. 2&3 2019. – 9 minutes – More at https://thehighwire.com/videos/ .
Prof. Heidi Larson, PhD – explains the problems with confidence of health care providers in vaccines
Professor of Anthropology, Risk and Decision Scientist. Director, Vaccine confidence project
… the other thing that’s a trend and an issue is not just confidence in providers but confidence of health care providers.
We have a very wobbly health professional frontline that is starting to question vaccines and the safety of vaccines!
That’s a huge problem because to this day any study I’ve seen and we’re constantly looking on any studies in this space, still the most trusted person on any study I have seen globally is the health care provider and if we lose that we’re in trouble
Global Vaccine Safety Summit Full version
1 hour, 33 minutes
Prof. Heidi Larson PhD – WHO
WHO Global Vaccine Safety Summit about misinformation.
“The problem with misinformation is not so simple, a lot of it is NOT mis-information”Prof. Heidi Larson PhD
Probably your most Important Covid Vaccine video Ever!
Listen to the testimony of many medical doctor’s and others.
Maybe most important, Senta Depuydt, a journalist alerting us about the pandemic accelerator act of the European Union (April 2020) allowing vaccine producers to have a free pass for safety.
On July 15 The European Parliament agreed to remove the need of risk evaluation requested under the GMO regulations. That decision was made in 10 days, without scientific reports or hearings in health Commission. No debate and no amendments prior to this vote.
Children’s Health Defense Europe has asked for the annulment of this decision in the European Court of Justice in Luxembourg.
Understand that the current covid vaccines are not proven safe.
Legislators have abandoned the principle of precaution by putting blind faith in a dangerous experiment. The current COVID vaccines are an experimental product based on the injection of genetic material into ourselves and the risk of using these new technologies on humans and the environment are unknown.
They could have Irreversible consequences.
Full lenght video:
Dr Andrew Kaufmann This pandemic is not a real medical pandemic.
The COVID-19 vaccine is not proven safe or effective because there is not been enough time. In addition there is not a clear definition of any new disease for which it can be tested against.
There has not been a virus that has been purified or shown to be the cause of an illness thus there is no target for a vaccine.
However the bottom line is that since no additional deaths have a occurred in relation to a new disease there is simply no need for a new vaccine
Dr Vernon Coleman (Minute 3:51)
Doctors aren’t allowed to question COVID-19 in public talking the truth about the alleged
disease and the vaccine.
I’ve been demonised and lied about and a 50 year career and reputation trashed by those promoting a pandemic that never was and a vaccine that was never needed. The whole COVID-19 scam is as I said in March 2020 the greatest hoax in history the principle of informed consent is essential in medicine.
Dr Piotr Rubas internist in Germany. (Minute 17:58)
I strongly disagree to getting vaccinated with this experimental Corona vaccine which is not proven safe or effective.
You should not expose your body to something unknown due to a virus which mortality rate is similar to that of
seasonal influenza virus. This is not a real medical pandemic.
I want you to remember that each one of you every single one of you independently is a beacon of light for those around you. So set the example stand up continue to fight continue to speak out especially for your children let your children see what it means to be free allow your children to witness your heroism and that you are willing to stand up and do what’s right regardless of what’s going on around you!
Why should current Covid-19 vaccines not be used for mass vaccination during a pandemic?
Dear colleagues at the WHO, my name is Geert Vanden Bossche.
My background is veterinary medicine. I’m a certified expert in microbiology and infectious diseases. I have a PhD in Virology and I have a long-standing career in human vaccinology.
I’m urging you to immediately open the scientific debate on how human interventions in the COVID-19 pandemic are currently driving viral immune escape.
I’m urging you to invite me for a scientific hearing open to the public and to scientists all over the world on this very topic. Ignoring or denying the impact of stringent infection prevention measures combined with mass vaccination using prophylactic vaccines is a colossal blunder.
Please do listen to my cry of distress and let’s first and foremost deliberate, on a scientifically justified strategy. To mitigate the tsunami of morbidity and lethality that is now threatening us.
And let’s meanwhile derive a strategy to eradicate the steadily emerging highly infectious variants. On behalf of humanity, I sincerely thank you for considering my call.
Dr G. Vanden Bossche, DVM, PhD -Independent Vaccine Research Consultant
Vaccines Summit Ohio 2021, March 1-3, 2021, Ohio, USA
I’ve attached the slides of the keynote that I held yesterday at the Vaccine Summit in Ohio (“Why should current Covid-19 vaccines not be used for mass vaccination during a pandemic?”). Please do have a look at them. The bottom-line is that I don’t see how mass vaccination campaigns would not lead to a disastrous aggravation of the Covid-19 pandemic. However, no one else seems to realize; instead, vaccinologists, clinicians and scientists are merely focusing on the (positive) short-term results and impact at an individual level. Nobody seems to be looking at the consequences and risk at a human population level (which, according to my understanding, will become manifest quite soon).
Why is nobody worried about ‘immune escape’ whereas Covid-19 has already escaped people’s innate immunity as reflected by multiple emerging, much more infectious, viral variants (most likely due to the global implementation of infection prevention measures)? Vaccine deployment in the ongoing mass immunization campaigns are highly likely to further enhance (adaptive) immune escape as none of the current vaccines will prevent replication/ transmission of viral variants. The more we use these vaccines for immunizing people in the midst of a pandemic, the more infectious the virus will become. With increasing infectiousness comes an increased likelihood of viral resistance to the vaccines. It’s not exactly rocket science, it’s a basic principle taught in a student’s first vaccinology class: One shouldn’t use a prophylactic vaccine in populations exposed to high infectious pressure (which is now certainly the case as multiple highly infectious variants are currently circulating in many parts of the world). To fully escape selective immune pressure exerted by vaccinal antibodies, Covid-19, a highly mutable virus, only needs to add another few mutations in its receptor-binding domain …
I am beyond worried about the disastrous impact this would have on our human ‘race’. Not only would people lose vaccine-mediated protection but also their precious, variant-nonspecific (!), innate immunity will be gone (this is because vaccinal antibodies outcompete natural antibodies for binding to Covid-19, even when their affinity for the viral variant is relatively low).
I’ve alerted all responsible health and regulatory authorities, including WHO, CDC, FDA etc. and have asked to consider my concern and to immediately open the discussion about the disastrous consequences any further immune escape of Covid-19 would have.
I know, of course, that current mass vaccination campaigns enjoy vigorous and world-wide support from a multitude of different parties/ stakeholders. However, unless I am proven wrong, this cannot be an excuse for ignoring that mankind may currently be transforming a quite harmless virus into an uncontrollable monster. I’ve never been that serious about a statement I made.
Geert Vanden Bossche Sharing his perspective on mass vaccination in COVID-19
Geert Vanden Bossche PhD, an internationally recognised vaccine developer having worked as the head of the Vaccine Development Office at the German Centre for Infection Research.
Coordinated Global Alliance for Vaccines and Immunisation’s Ebola Vaccine Program and contributed to the implementation of an integrated vaccine work plan in collaboration with Global Health Partners (WHO, Bill & Melinda Gates Foundation, CDC, UNICEF), regulators (FDA) and vaccine manufacturers to enable timely deployment or stockpiling of Ebola vaccine candidates.
Highlighting the principle of using a prophylactic vaccine in the midst of a pandemic. Likely to create more more viral variants in the process. Sharing his perspective on mass vaccination in COVID-19.
Deep Dive Questions and Answers with Geert Vanden Bossche and Dr Philip McMillan
Website Geert Vanden Bossche https://www.geertvandenbossche.org/
Dr Vernon Coleman – March 13, 2021
Now more than ever, I need your help. Unless we work together, we are doomed.
I need your help because we need to reach millions with this video and with the big platforms and the mainstream media having banned me, I can’t reach those millions without you. I believe this is the most important video. I will ever make and the most important you will ever see.
I fear that the genocidal lunatics, the horsemen of the Apocalypse who planned this fraud are leading us into Armageddon.
Millions have received one of the COVID-19 vaccines may die as a result of those vaccinations. But the politicians and the advisers did everything wrong. And those who questioned what was happening were demonised and silenced.
The public were originally assured that only through a huge vaccination program could they possibly win back some of their last freedoms. This was always dangerous nonsense.
The 1st problem is that these experimental vaccines have already proved to be desperately dangerous, killing many people already and producing serious adverse events in many more. The size of this particular problem can be judged by the fact that even the authorities admit that probably only one in 100 vaccine related deaths and serious injuries will be reported. It’s impossible to estimate how many will die of allergy problems, heart trouble, strokes, neurological problems, and so on. Or how many would be blinded or paralysed?
The 2nd problem is the immune system problem, known as pathogenic priming or cytokine storm. What happens is that the immune system of the person who’s been vaccinated will be primed to respond in a very dramatic way If that individual comes into contact with the virus in the future.
The result can be catastrophic, and this is what I fear will happen in the autumn and during next winter. The people who’ve had the vaccine are going to be in real trouble when they next come into contact with the coronavirus. Their immune systems will overreact, and that’s likely to be when they will be lots of deaths.
Patients haven’t been officially warned about this problem, although the evidence was published in the International Journal of Clinical Practice for October last year. The paper entitled Informed Consent Disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease. But there’s been no informed consent for patients, and I suspect that most doctors remain ignorant of the risks.
Patients are being told that there are no dangers with these vaccines. The elderly and those with poor immune systems are particularly likely to be killed.
The coronavirus spreads most rapidly in autumn and winter. As a result of the epidemic of illnesses and deaths that will take place, governments will start promoting the next round of vaccinations. There will be much talk of mutations and new horridly prepared experimental vaccines will be produced and heavily promoted.
And this brings us to the 3rd problem, a problem. I don’t think they expected. This problem is just being outlined by Dr Geert Vanden Bossche, who’s a very eminent vaccine specialist. Indeed, I was originally skeptical about what he said because Dr Vanden Bossche has previously worked with Gavin, the Gates Foundation. He’s the last person in the world who could be described as being opposed to vaccination. He pointed out that the vaccines which are currently being used are the wrong weapons to use for this war against the virus infection. Disastrously by giving vaccines to millions, teaching the virus, how to mutate and to become stronger and more deadly.
Trying to devise new vaccines for new mutations simply makes things worse because the scientists can’t possibly get ahead of the mutated viruses and the people who have been vaccinated and now sharing mutated viruses with those around them from the mutations are becoming stronger and deadlier. Ending the lockdowns will be perfectly timed to ensure that new mutations of the COVID-19 virus are spread far and wide.
There’s another associated problem too. Normally our bodies contain white blood cells, which help us defeat infections cells called NK cells. Once the NK cells have done their work our antibodies appear and clean up the mess.
However, Dr Vanden Bossche explains that the COVID-19 vaccines are triggering the production of very specific antibodies which compete with the natural defences of the individuals who’ve had the vaccines.
The Natural defence systems of those who been vaccinated are being suppressed because the specific antibodies which have been produced by the vaccine just take over, and these specific antibodies, the ones produced by the vaccines, are permanent there forever within the bodies of the people who had been vaccinated.
The disastrous result is that the natural immune systems of the 10s or hundreds of millions who are having the vaccines are being effectively destroyed.
Their immune systems will not be able to fight any mutated variation of the virus which develops within their bodies.
And those mutated viruses can spread out into the community. I believe This is why new virus variations are appearing in areas where the vaccine has been given to lots of people.
The bottom line is that giving the vaccines will give the virus an opportunity to become infinitely more dangerous. Every vaccinated individual has the potential to become a mass murderer because their bodies are becoming laboratories, making lethal viruses and worse still, some of the vaccinated individuals may become asymptomatic carriers, spreading lethal viruses around them.
The people who’ve had the vaccine won’t be able to respond to the mutations because their immune systems have been taken over by an artificial defence system given to them by the vaccine. Undesigned to combat the original form of the COVID-19 virus. The vaccinated individuals are going to be very much at risk when the new mutations start to spread.
Giving new vaccines won’t help because the mutated virus will not be vulnerable. The scientists who are making vaccines won’t be able to get ahead of the mutating virus.
If Dr Vanden Bossche is right and I believe he is, then it’s the vaccinated individuals who are going to threaten mankind. They’ll be a major threat to anyone who’s been vaccinated. But they’ll also be a major threat to the under vaccinated because the viruses there shedding are going to be more dangerous than the original one.
We are in very dangerous territory if we don’t stop this vaccine program now, then it’s no exaggeration to say that the very future of mankind is at risk.
SARS-CoV-2 immunity-escape variants, 7 January 2021
Paper prepared by academics for NERVTAG on viral evasion during antibody treatment of the new SARS-CoV 2 immunity-escape variants. It was considered at SAGE 75 on 7 January 2021.
- Concerns have been raised about the possible emergence of SARS-CoV-2 variants that escape immune recognition because of:
- The recent identification of two SARS-CoV-2 variants (one in the UK and the other in South Africa) with apparently increased transmission and substitutions in the receptor binding domain (RBD) on the spike protein that theoretically might be associated with immune escape;
- High levels of SARS-CoV-2 incidence in the community in the UK associated with a variant B.1.1.7;
- The decision in the UK to provide the second dose of SARS-CoV-2 vaccine at 12 weeks rather than 3 weeks after the first dose.
- This paper explores the possibility that SARS-CoV-2 escape variants that are partially or fully resistant to natural immunity, vaccination or antibody therapies may have arisen or will arise.
Particularly in immune suppressed individuals with prolonged viral replication, viral evasion can occur during antibody-based treatment. However, the overall impact of these escape variants on clinical and virological outcomes are not clear.
Circulating SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies.
Cross-neutralization of B.1.351 variants was weak and comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses.
While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizing humoral immunity and emphasize the need to develop broadly protective interventions against the evolving pandemic.
In summary, our data highlights the challenges facing all vaccines whose designs were finalized early in the pandemic and based on the sequence of the first-reported virus from Wuhan, China.
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
• Numerous variants of SARS-CoV-2-harboring mutations in spike have arisen globally
• mRNA vaccines elicit potent neutralizing activity against homologous pseudovirus
• Cross-neutralization of strains with receptor-binding domain (RBD) mutations is poor
• Both RBD and non-RBD mutations mediate escape from vaccine-induced humoral immunity
Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2. Five of the 10 pseudoviruses, harboring receptor-binding domain mutations, including K417N/T, E484K, and N501Y, were highly resistant to neutralization. Cross-neutralization of B.1.351 variants was comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses. While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizing humoral immunity and emphasize the need to develop broadly protective interventions against the evolving pandemic.
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies
• B.1.1.7, B.1.351 and P.1 do not show augmented host cell entry
• Entry inhibitors under clinical evaluation block all variants
• B.1.351 and P.1 can escape from therapeutic antibodies
• B.1.351 and P.1 evade antibodies induced by infection and vaccination
The global spread of SARS-CoV-2/COVID-19 is devastating health systems and economies worldwide. Recombinant or vaccine-induced neutralizing antibodies are used to combat the COVID-19 pandemic. However, the recently emerged SARS-CoV-2 variants B.1.1.7 (UK), B.1.351 (South Africa) and P.1 (Brazil) harbor mutations in the viral spike (S) protein that may alter virus-host cell interactions and confer resistance to inhibitors and antibodies. Here, using pseudoparticles, we show that entry of all variants into human cells is susceptible to blockade by the entry inhibitors soluble ACE2, Camostat, EK-1 and EK-1-C4. In contrast, entry of the B.1.351 and P.1 variant was partially (Casirivimab) or fully (Bamlanivimab) resistant to antibodies used for COVID-19 treatment. Moreover, entry of these variants was less efficiently inhibited by plasma from convalescent COVID-19 patients and sera from BNT162b2 vaccinated individuals. These results suggest that SARS-CoV-2 may escape neutralizing antibody responses, which has important implications for efforts to contain the pandemic.
mRNA Vaccine Induced Damage mechanisms
Dr. Loretta Bolgan
The various mechanisms by which COVID-19 vcaccines can induce immunopathologies.
Sars-Cov-2, could certinaly be responsible for the phenomenon of disease enhancement in vaccinees, which should have been investigated and excluded before proceeding with human trials.
Given the similarity between the mechanisms of COVID-19 damage and vaccine adverse reactions, it is conceivable that many of the symptoms and pathologies associated with long-COVID may also be present as long-term consequences of vaccination.
Long read -34 pages
Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease
Results of the study: COVID-19 vaccines designed to elicit neutralising antibodies may sensitise vaccine recipients to more severe disease than if they were not vaccinated. Vaccines for SARS, MERS and RSV have never been approved, and the data generated in the development and testing of these vaccines suggest a serious mechanistic
that vaccines designed empirically using the traditional approach (consisting of the unmodified or minimally modified coronavirus viral spike to elicit neutralising antibodies), be they composed of protein, viral vector, DNA or RNA and irrespective of delivery method, may worsen COVID-19 disease via antibody-dependent enhancement (ADE).
This risk is sufficiently obscured in clinical trial protocols and consent forms for ongoing COVID-19 vaccine trials that adequate patient comprehension of this risk is unlikely to occur, obviating truly informed consent by subjects in these trials.
Given the strong evidence that ADE is a non-theoretical and compelling risk for COVID-19 vaccines and the “laundry list” nature of informed consents, disclosure of the specific risk of worsened COVID-19 disease from vaccination calls for a specific, separate, informed
consent form and demonstration of patient comprehension in order to meet medical ethics standards.
The informed consent process for ongoing COVID-19 vaccine trials does not appear to meet this standard.
While the COVID-19 global health emergency justifies accelerated vaccine trials of candidates with known liabilities, such an acceleration is not inconsistent with additional attention paid to heightened informed consent procedures specific to COVID-19 vaccine risks.
Vaccine opinions by Scientists
Is a Coronavirus Vaccine a Ticking Time Bomb?
Dr Doug Corrigan.
Ph.D. in Biochemistry and Molecular Biology, a master’s in Engineering Physics (concentration: Solid State Physics), and a bachelor’s in Engineering Physics (concentration: electrical engineering.)
Will a vaccine to SARS-CoV-2 actually make the problem worse? Although not a certainty, all of the current data says that this prospect is a real possibility that needs to be paid careful attention to. If you stay with me, I’ll explain why.
Prof. Dr Dolores Cahill Molecular Biologist, Immunologist
Immune system can save everyone from Covid-19; No one needs to die from Covid-19, flu symptoms can be avoided and the new mRNA vaccines are deadly.
So says molecular biologist and immunologist, Ph.D. Dolores Cahill, for Update, which we met at an event in Copenhagen, organized by the World Freedom Alliance.
Cahill is an international expert on the immune system and vaccines and has decades of research behind him.
In parallel, she has held a number of international top positions for e.g. for the European Commission. She tells in the interview which vitamins, minerals and preparations can save everyone from dying of Covid-19, reduce flu symptoms and provide security for the elderly with poor health.
Her warnings against the new mRNA vaccines cannot be overstated.
She would rather go to jail than be vaccinated with them, and if someone – against her will – gave her an injection, she would prosecute them for attempted murder.
Prior to May 2020, there were no approved mRNA vaccines, due to high mortality rates in the trials that may occur months or years after vaccination. According to Cahill, doctors, politicians and big-tech should be held directly and criminally accountable when they dissuade the population from vital information, prevention and proper treatment.
mRNA vaccines dangers – Dolores Cahill and Alexandra Henrion-Caude
Prof. Dr Dolores Cahill Molecular Biologist, Immunologist https://www.researchgate.net/profile/Dolores_Cahill
Alexandra Henrion-Caude, biomedical researcher.Patents for bioinformatic tool in microRNA field: MIRIFIX. Grantee, European, Inserm, French and Canada Association, 2001-2010. https://www.researchgate.net/profile/Alexandra_Henrion-Caude
Video starting at 8m:35s -Alexandra Henrion-Caude
The informed consent to be disclosed to any vaccine trial subjects, which is in fact any person who is currently being vaccinated. The risk of COVID-19 vaccines worsening clinical disease.
Especially given the response of the Th2 lymphocytes, a specific response that can take place in elderly! It is highly expected that elderly people will be more at risk actually of all the procedures
The conclusion leaves no place for interpretation! It is an ethical aspect that we should be raising! The specific and significant COVID19 vaccine risk of ADE (antibody dependent enhancement).
It should be prominently and independently disclosed to research subjects currently in vaccine trials as well as those being recruited for the trials and future patients after vaccine approval in order to meet the medical ethics standards of patient comprehension for informed consent.
Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease https://pubmed.ncbi.nlm.nih.gov/33113270/
Conclusions drawn from the study and clinical implications: The specific and significant COVID-19 risk of ADE should have been and should be prominently and independently disclosed to research subjects currently in vaccine trials, as well as those being recruited for the trials and future patients after vaccine approval, in order to meet the medical ethics standard of patient comprehension for informed consent.
Professor Dr Dolores Cahill Why people will start dying a few months after the 1st mRNA vaccinations
Professor Dr Dolores Cahill Explains “Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus”
Acces the report on the NIH website via this link or download the saved copy below
Dr Wolfgang Wodarg Dec 3, 2020 – Concerns over the health and safety
Concerns over the health and safety of the human test subjects in Pfizer’s European COVID vaccine study have caused two eminent doctors to launch a petition calling for an immediate halt to those studies.
On December 1, 2020, Dr. Michael Yeadon, an ex chief of research at Pfizer and Dr. Wolfgang Wodarg, a lung specialist and former department head of public health lodged an appeal to the EMA, the European Medicine Agency responsible for approving drugs across the EU, asking them to suspend the ongoing Pfizer/BioNtech COVID vaccine study on BNT162b (EudraCT number 2020-002641-42).
Dr. Mike Yeadon No need for vaccines, ‘the pandemic is effectively over’
Pfizer’s former Vice President and Chief Scientist for Allergy & Respiratory, states that the drive for a universal vaccine has ‘the whiff of evil’ which he ‘will oppose … vigorously.’
There is absolutely no need for vaccines to extinguish the pandemic. I’ve never heard such nonsense talked about vaccines. You do not vaccinate people who aren’t at risk from a disease. You also don’t set about planning to vaccinate millions of fit and healthy people with a vaccine that hasn’t been extensively tested on human subjects.
Dr. James Lyons-Weiler | PA Medical Freedom Press Conference
PA Medical Freedom Press Conference 10/20/20 – Opposing Covid vaccine mandates and medical care discrimination.
Research scientist James Lyons – Weiler, PhD, is President and CEO of The Institute for Pure and Applied Knowledge , Founder of IPAK-EDU.org, and the author of “Cures vs. Profits“, “Environmental and Genetic Causes of Autism“, and “Ebola:An Evolving Story” Dr. Lyons-
Weiler has been conducting biomedical research for over 20 years and has 58 peer-reviewed publications.
After earning a PhD in Ecology, Evolution & Conservation in Biology, he won an AP Sloan Postdoctoral Fellowship in Computational Molecular Biology at Pennsylvania State University.
Prior to founding IPAK and IPAK-EDU, he was a full faculty member at the University of Pittsburgh Cancer Institute, faculty in the Department of Pathology in the School and Medicine at the University of Pittsburgh, and Senior Research Scientist/Scientific Director of the University of Pittsburgh’s Bioinformatics Analysis Core in support of translational research, systems biology, sequence analysis, and the creation of novel algorithmic solutions for the analysis of complex and challenging data.
Prof. Francis Boyle -Do Not Take These Frankenshots!
Prof Boyle has some very strong statements about the Pfizer and Moderna mRNA vaccine.
Prof Boyle drafted the US domestic implementing legislation for the Biological Weapons Convention, known as the Biological Weapons Anti-Terrorism Act of 1989, that was approved unanimously by both Houses of the US Congress and signed into law by President George H.W. Bush.
I deliberately copied the above from his CV since he is drawing a direct parallel with the vaccination of US soldiers serving in the 1st Gulf war. He calls this war-crimes breaking the Nuremberg code with experiments on the vaccines for these soldiers. 500.000 troops inoculated, 11.000 were killed and 100,000 were disabled and those were healthy young men and women in US armed forces
Those experimental vaccines have been approved under the same emergency approval procedure as the COVID-19 vaccine.
Further more he states that COVID19 is an offensive biological warfare weapon Biosafety Level 4 laboratory (BSL-4) from which he believes the infectious disease escaped. Which is China’s equivalent to Fort Detrick and they have to wear moon suits and portable air supplies showing dangerous it is in these facilities. COVID-19 was developed not only at the Wuhan BSL 4 but also at the University of North Carolina bio safety Level 3 land. Doctor Shi Zhengli, the black Queen from Wuhan BSL 4 took a synthetic recombinant virus using synthetic biology making it more lethal and more infectious.
Prof Boyle is not the only scientist talking about a laboratory as the origin for the covid-19 virus. Prof. Luc Montagnier “Virus is Manipulated. A very Meticulous job”
Norwegian virologist Birger Sørensen “I firmly believe that it was spread by accident. When US authorities conducted an inspection in Wuhan in 2018, it was described as a risk lab.
More details on the main blog
The text below copied from Youtube. I saved the video because I don’t believe it will last long on Youtube.
Prof Boyle talks to Jason Liosatos warning us not to take to the Frankenshots and explains why
Support Jason’s work here https://www.patreon.com/JasonLiosatos
See my previous talks with Prof. Francis Boyle this year here:
Feb 2020 https://www.youtube.com/watch?v=5snzK…
March 2020 https://www.youtube.com/watch?v=L5rEm…
April 2020 https://www.youtube.com/watch?v=n2vGn…
Jason’s book and website: http://jasonliosatos.com/
See all Jason’s shows here https://www.youtube.com/user/GlobalPe…
Jason’s online art classes https://jasonliosatosartclasses.com/
Prof. Dr. Sucharit Bhakdi (Germany) – interview Laura Ingraham
December 2, 2020 – LAURA INGRAHAM (HOST): Doctor, on the issue of the vaccine, tonight, Anthony Fauci, on this network, actually said that 75 percent of Americans are going to have to get vaccinated to reach what they call “herd immunity”. Do you — do you buy that?
DR. SUCHARIT BHAKDI (GUEST): What utter nonsense. I know that Dr. Fauci is a renowned
GUEST: medical scientist and immunologist. But what he says has to be wrong. And this is also what we have taken great lengths to explain in the book. And why — you know, someone who says this, has not the slightest inkling of the basics of immunology. And this is very, very surprising for someone of Dr. Fauci’s standing. And I would dare to defy him anywhere in the world at any time. But I cannot do this in 2 minutes.
INGRAHAM: Well, so you believe that the COVID vaccine is not necessary?
BHAKDI: I think it’s downright dangerous. And I warn you, if you go along these lines, you are going to go to your doom. And it’s so, so unnecessary.
Then the video ends abrupt because they don’t have more time ….
Prof. Dr. Pierre Capel – Frikandel 3.0
Unfortunately this video is in the Dutch language without sub-titles
More from Professor emeritus FOR THE JOY OF SCIENCE http://www.pierrecapel.nl/
Severe reactions, Reinfection, Reverse transcription, Genome integration?
COVID-19 RNA Based Vaccines and the Risk of Prion Disease
Development of new vaccine technology has been plagued with problems in the past. The current RNA based SARS- CoV-2 vaccines were approved in the US using an emergency order without extensive long term safety testing.
In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients. The RNA sequence of the vaccine as well as the spike protein target interaction were analyzed for the potential to convert intracellular RNA binding proteins TAR DNA binding protein (TDP-43) and Fused in Sarcoma (FUS) into their pathologic prion conformations.
The results indicate that the vaccine RNA has specific sequences that may induce TDP-43 and FUS to fold into their pathologic prion confirmations. In the current analysis a total of sixteen UG tandem repeats (ΨGΨG) were identified and additional UG (ΨG) rich sequences were identified. Two GGΨA sequences were found. Potential G Quadruplex sequences are possibly present but a more sophisticated computer program is needed to verify these. Furthermore, the spike protein, created by the translation of the vaccine RNA, binds angiotensin converting enzyme 2 (ACE2), a zinc containing enzyme. This interaction has the potential to increase intracellular zinc. Zinc ions have been shown to cause the transformation of TDP-43 to its pathologic prion configuration. The folding of TDP-43 and FUS into their pathologic prion confirmations is known to cause ALS, front temporal lobar degeneration, Alzheimer’s disease and other neurological degenerative diseases.
The enclosed finding as well as additional potential risks leads the author to believe that regulatory approval of the RNA based vaccines for SARS-CoV-2 was premature and that the vaccine may cause much more harm than benefit.
36 COVID-19 vaccine recipients develop rare blood disorder after getting Moderna, Pfizer
This Side-Effect Is Not Age Or Gender Specific
Earlier this week, a report in the New York Times highlighted the fact that around 36 reports of this rare blood disorder, also called immune thrombocytopenia (ITP), was submitted to the federal government’s Vaccine Adverse Event Reporting System (VAERS).
A Florida physician has also reportedly died of the condition in January. The cases are equally divided between Pfizer and Moderna, manufacturers of the two COVID vaccines currently approved in the US, and they don’t seem to be age- or gender-specific. But experts are not very sure if the shots really did cause the problem, or if these people developed immune thrombocytopenia anyway. Some think that it is just a coincidence that symptoms surfaced post-vaccination.
Rudolf Jaenisc – SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome
Prolonged SARS-CoV-2 RNA shedding and recurrence of PCR-positive tests have been widely reported in patients after recovery, yet these patients most commonly are non-infectious1–14.
Here we investigated the possibility that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome and that transcription of the integrated sequences might account for PCR-positive tests.
In support of this hypothesis, we found chimeric transcripts consisting of viral fused to cellular sequences in published data sets of SARS-CoV-2 infected cultured cells and primary cells of patients, consistent with the transcription of viral sequences integrated into the genome.
In this study, we showed evidence that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome by several sources of reverse transcriptase such as activated human LINE-1 or co-infected retrovirus (HIV). We found LINE-1 expression can be induced upon SARS-CoV-2 infection or cytokine exposure, suggesting a molecular mechanism responsible for SARS-CoV-2 retro-integration in patients.
Moreover, our results suggest that the integrated SARS-CoV-2 sequences can be transcribed, as shown by RNA-Seq and smRNA-FISH data, providing a possible explanation for the presence of viral sequences at later times after initial virus exposure and in the absence of detectable infectious virus1–14.
Biography Rudolf Jaenisch; one of the co-writers in this study
Whitehead Institute for Biomedical Research, Cambridge, MA, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
Study: SARS-CoV-2 RNA can be reverse-transcribed to be part of chimeric viral-human genome.
A study appearing as a preprint on the bioRxiv* server in December 2020 reveals that the genome of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is inserted into the human genome, accounting for the detection of viral RNAs, even in late convalescence.
Multiple cases of apparent reinfection have been reported over the past year. Though some have been rigorously investigated and found to be genuine cases of reinfection, evidenced by the presence of different strains of SARS-CoV-2 in the two episodes, it seems unlikely that this is the case with most. Additionally, no replication-competent virus has been isolated.
Implications and future directions
“Our results show induced LINE-1 expression in cells stressed by viral infection or exposed to cytokines, suggesting a molecular mechanism for SARS-CoV-2 retro-integration in human cells.”
- Chimeric reads present in published RNA sequences
- Sources of RT activity: LINE-1 or HIV-1
- N sequences found in the cell nucleus
- LINE-1 and cytokines mediate reverse transcription
Informed consent disclosure to vaccine trial subjects of risk of COVID‐19 vaccines worsening clinical disease
Results of the study
COVID‐19 vaccines designed to elicit neutralising antibodies may sensitise vaccine recipients to more severe disease than if they were not vaccinated. Vaccines for SARS, MERS and RSV have never been approved, and the data generated in the development and testing of these vaccines suggest a serious mechanistic concern: that vaccines designed empirically using the traditional approach (consisting of the unmodified or minimally modified coronavirus viral spike to elicit neutralising antibodies), be they composed of protein, viral vector, DNA or RNA and irrespective of delivery method, may worsen COVID‐19 disease via antibody‐dependent enhancement (ADE). This risk is sufficiently obscured in clinical trial protocols and consent forms for ongoing COVID‐19 vaccine trials that adequate patient comprehension of this risk is unlikely to occur, obviating truly informed consent by subjects in these trials.
Conclusions drawn from the study and clinical implications
The specific and significant COVID‐19 risk of ADE should have been and should be prominently and independently disclosed to research subjects currently in vaccine trials, as well as those being recruited for the trials and future patients after vaccine approval, in order to meet the medical ethics standard of patient comprehension for informed consent.
1 THE RISK OF ADE IN COVID‐19 VACCINES IS NON‐THEORETICAL AND COMPELLING
2 CHALLENGES TO INFORMED CONSENT FOR COVID‐19 VACCINE STUDIES
Given the strong evidence that ADE is a non‐theoretical and compelling risk for COVID‐19 vaccines and the “laundry list” nature of informed consents, disclosure of the specific risk of worsened COVID‐19 disease from vaccination calls for a specific, separate, informed consent form and demonstration of patient comprehension in order to meet medical ethics standards. The informed consent process for ongoing COVID‐19 vaccine trials does not appear to meet this standard. While the COVID‐19 global health emergency justifies accelerated vaccine trials of candidates with known liabilities, such an acceleration is not inconsistent with additional attention paid to heightened informed consent procedures specific to COVID‐19 vaccine risks.
First published: 28 October 2020 https://doi.org/10.1111/ijcp.13795
Dr Doug -Will an RNA Vaccine Permanently Alter My DNA?
Posted by Dr. Doug Posted in COVID-19, vaccine
My professional opinion is that since RNA vaccines are a new mode of delivering vaccines, they should be tested for 5-10 years to demonstrate that genetic modification is not a major concern.
In addition, all coronavirus vaccines, regardless of type, should be tested for an equal duration to show that ADE is not a concern.
It is absolutely impossible to rule out these safety concerns in less than a year.
Dr Peter Borger -The facts are that RNA vaccins can potentially change your DNA
The science facts are that RNA vaccins can potentially change your DNA. To understand how, we have to go a bit into genomics. Our genome contains about 50-60 thousand genes (~20 thousand protein-coding genes, the rest RNA genes). Together they make up about 25% of the genome.
In addition to that, our genome contains about 50% so called transposable and transposed elements (TEs), including ERVs and LINEs. The latter function, among other things, as (epi)genetic switches to control when genetic programs are switched on and off.
Interestingly, ERVs and LINEs both posses genes for the enzymes “reverse transcriptase (RT)” and “integrase” (INT). The RT enzyme converts RNA into cDNA, whereas the INT enzyme can put cDNA back into the genome. They prefer doing this with viral-like RNA molecules.
Further, RNA vaccins use viruses as their genetic backbones. RNA vaccins contain viral RNAs. With thousands of copies of RT and INT genes in our genomes there is ample opportunity to put any viral RNA back into our DNA. So, RNA vaccins are potentially “genotoxic”.
“Genotoxic” means that the “RNA–>cDNA–>genome integration” mechanism can lead to disturbed genetic control. In the long run, that may lead to genetic abberations and disease. It should be noted that RNA vaccins were not tested to exclude above described genotoxicy.
Above text copied from Tweet below
Dr Andrew Wakefield -Messenger RNA vaccine is actually genetic engineering
Explaining why by definition a RNA vaccine isn’t a vaccine at all.
What could possibly go wrong, the potential for this to go horribly wrong is enormous it’s never been used in humans before it’s never been tested out and yet it’s been rushed to market. No liability for vaccines so they can shortcuts safety studies they can rush to market they don’t mind because they’re not going to pay a price for it they don’t pick up the tab for the damage done. The full interview in a pdf for download below the video
And for those who would like to discredit Dr Andrew Wakefield listen to the video below:
Del Bigtree sets the record straight over Andrew Wakefield
An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development
Although these beneficial features of mRNA vaccines provide some hope for the development of the first clinically applicable SARS-CoV-2 mRNA vaccine, recent reports regarding rare cases of moderate or severe reactions for different mRNA vaccines have raised concerns about safety and immunogenicity, including in the primary outcome findings of the phase I trial on mRNA-1273 [20,48]. Therefore, it is important to clearly understand the potential risks of this type of mRNA-based vaccine, which include local and systemic inflammatory responses, the biodistribution and persistence of the induced immunogen expression, possible development of autoreactive antibodies and toxic effects of any non-native nucleotides and delivery system components [48–50].
Therefore, it is important to clearly understand the potential risks of this type of mRNA-based vaccine, which include local and systemic inflammatory responses, the biodistribution and persistence of the induced immunogen expression, possible development of autoreactive antibodies and toxic effects of any non-native nucleotides and delivery system components [48–50].
mRNA vaccines — a new era in vaccinology
Nature Reviews Drug Discovery volume 17, 261–279(2018)
Potential safety concerns that are likely to be evaluated in future preclinical and clinical studies include local and systemic inflammation, the biodistribution and persistence of expressed immunogen, stimulation of auto-reactive antibodies and potential toxic effects of any non-native nucleotides and delivery system components.
A possible concern could be that some mRNA-based vaccine platforms54,166 induce potent type I interferon responses, which have been associated not only with inflammation but also potentially with autoimmunity167,16.
Thus, identification of individuals at an increased risk of autoimmune reactions before mRNA vaccination may allow reasonable precautions to be taken.
While preclinical studies have generated great optimism about the prospects and advantages of mRNA-based vaccines, two recent clinical reports have led to more tempered expectations22,91. In both trials, immunogenicity was more modest in humans than was expected based on animal models, a phenomenon also observed with DNA-based vaccines171, and the side effects were not trivial.
In a Twist, Scientists Find Cancer Drivers Hiding in RNA, Not DNA
2 Articles …
1) the original publication from 2018 – the Sloan Kettering Institute
Researchers at the Sloan Kettering Institute have found that changes in an information-carrying molecule called messenger RNA can inactivate tumor-suppressing proteins and thereby promote cancer. The findings pinpoint previously unknown drivers of the disease.
2) Sceptic article from Naturalnews alarming the effect mRNA vaccination
MEDICAL SHOCKER: Scientists at Sloan Kettering discover mRNA inactivates tumor-suppressing proteins, meaning it can promote cancer.
After your Covid vaccination, RNA is transported out of your cell’s nucleus, and will no longer function properly as a cancer tumor suppressor
Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia
DNA mutations are known cancer drivers. Here we investigated whether mRNA events that are upregulated in cancer can functionally mimic the outcome of genetic alterations.
RNA sequencing or 3′-end sequencing techniques were applied to normal and malignant B cells from 59 patients with chronic lymphocytic leukaemia (CLL)1,2,3.
We discovered widespread upregulation of truncated mRNAs and proteins in primary CLL cells that were not generated by genetic alterations but instead occurred by intronic polyadenylation. Truncated mRNAs caused by intronic polyadenylation were recurrent (n = 330) and predominantly affected genes with tumour-suppressive functions. The truncated proteins generated by intronic polyadenylation often lack the tumour-suppressive functions of the corresponding full-length proteins (such as DICER and FOXN3), and several even acted in an oncogenic manner (such as CARD11, MGA and CHST11). In CLL, the inactivation of tumour-suppressor genes by aberrant mRNA processing is substantially more prevalent than the functional loss of such genes through genetic events. We further identified new candidate tumour-suppressor genes that are inactivated by intronic polyadenylation in leukaemia and by truncating DNA mutations in solid tumours4,5.
These genes are understudied in cancer, as their overall mutation rates are lower than those of well-known tumour-suppressor genes. Our findings show the need to go beyond genomic analyses in cancer diagnostics, as mRNA events that are silent at the DNA level are widespread contributors to cancer pathogenesis through the inactivation of tumour-suppressor genes.
Professor Sunetra Gupta – Herd immunity Presentation
Sunetra Gupta (born 15 March 1965) is a British-Indian infectious disease epidemiologist and a professor of theoretical epidemiology at the Department of Zoology, University of Oxford. She has performed research on the transmission dynamics of various infectious diseases, including malaria, influenza and COVID-19, and has received the Scientific Medal of the Zoological Society of London and the Rosalind Franklin Award of the Royal Society.
Covid-19 immunity likely lasts for years, according to a new study.
A new study shows immune cells primed to fight the coronavirus should persist for a long time after someone is vaccinated or recovers from infection.
“There was a lot of concern originally that this virus might not induce much memory,” says Shane Crotty, a researcher at the La Jolla Institute for Immunology in California and a coauthor of the new paper. “Instead, the immune memory looks quite good.”
A study published in August showed that T cells specific to SARS can remain in the blood for at least 17 years, bolstering hopes that covid-19 immunity could last for decades.
Note: You find the referred study from August further down on this page
Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection
The results clearly indicate that most of the recovered COVID-19 patients have developed effective T cell memory pools against SARS-CoV-2.
To assess the SARS-CoV-2-specific T-cell memory, human peripheral blood mononuclear cells (PBMCs) from 90 COVID-19 patients collected between 48–86 days after disease onset were stimulated in vitro for 10 days with peptide pools designed to target the spike glycoprotein (S), membrane glycoprotein (M), nucleocapsid (N), envelope glycoprotein (E) and ORF1ab region of RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. Our data showed that the memory CD4+ and CD8+ T cells of 94.44% and 83.33%, respectively, of the COVID-19 patients successfully underwent expansion
Here we report virus-specific CD4+ and CD8+ T-cell memory in recovered COVID-19 patients and close contacts.
We also demonstrate the size and quality of the memory T-cell pool of COVID-19 patients are larger and better than those of close contacts. However, the proliferation capacity, size and quality of T-cell responses in close contacts are readily distinguishable from healthy donors, suggesting close contacts are able to gain T-cell immunity against SARS-CoV-2 despite lacking a detectable infection. Additionally, asymptomatic and symptomatic COVID-19 patients contain similar levels of SARS-CoV-2-specific T-cell memory. https://www.nature.com/articles/s41467-021-22036-z
Your Immune System Evolves to Fight Coronavirus Variants
Antibodies can change to counter new forms of the shape-shifting virus, research hints
By Monique Brouillette on March 31, 2021
“Essentially, the immune system is trying to get ahead of the virus,” says Michel Nussenzweig, an immunologist at the Rockefeller University, who conducted some recent studies that tracked this phenomenon. The emerging idea is that the body maintains reserve armies of antibody-producing cells in addition to the original cells that responded to the initial invasion by SARS-CoV-2, the virus that causes COVID. Over time some reserve cells mutate and produce antibodies that are better able to recognize new viral versions. “It’s really elegant mechanism that that we’ve evolved, basically, to be able to handle things like variants,” says Marion Pepper, an immunologist at the University of Washington, who was not involved in Nussenzweig’s research. Whether there are enough of these cells, and their antibodies, to confer protection against a shape-shifting SARS-CoV-2 is still being figured out.
Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases
Open Access Published:January 26, 2021 DOI: https://doi.org/10.1016/j.xcrm.2021.100204
Alison Tarke, John Sidney, Conner K. Kidd, Jennifer M. Dan, Sydney I. Ramirez, Esther Dawen Yu, Jose Mateus, Ricardo da Silva Antunes, Erin Moore, Paul Rubiro, Nils Methot, Elizabeth Phillips, Simon Mallal, April Frazier, Stephen A. Rawling, Jason A. Greenbaum, Bjoern Peters, Davey M. Smith, Shane Crotty, Daniela Weiskopf, Alba Grifoni, Alessandro Sette
T-cell responses recognize at least 30–40 epitopes in each donor
Immunodominance is correlated with HLA binding
Immunodominant regions for CD4+ T cells have minimal overlap with antibody epitopes
CD8+ T cell responses depend on the repertoire of HLA class I alleles
In this study, we report a comprehensive map of epitopes recognized by CD4+ and CD8+ T cell responses across the entire SARS-CoV-2 viral proteome. Importantly, these epitopes have been characterized in the context of a broad set of HLA alleles using a direct ex vivo, cytokine-independent approach.
Several studies have reported significant pre-existing immune memory to SARS-CoV-2 peptides in unexposed donors.1,3,4,15This reactivity was shown to be associated, at least in some instances, with memory T cells specific for human CCCs cross-reactively recognizing SARS-CoV-2 sequences.3,15 In particular, it was shown that the SARS-CoV-2 epitopes recognized in unexposed donors had significantly higher homology to CCC than SARS-CoV-2 sequences not recognized in unexposed donors.
This study presents a comprehensive analysis of the patterns of epitope recognition associated with SARS-CoV-2 infection in a cohort of approximately 100 different convalescent donors spanning a range of peak COVID-19 disease severity representative of the observed distribution in the San Diego area.
We are not aware of any study that describes the repertoire of CD4+ and CD8+ T cell epitopes recognized in SARS-CoV-2 infection with a comparable level of granularity or breadth.
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.
T-cells Are the Superstars in Fighting COVID-19
Sept. 24, 2020 By Eshani M King, Evidence Based Research in Immunology and Health
German researchers found that a staggering 81% of individuals had pre-existing T-cells that cross-react with SARS-CoV-2 epitopes. This fits with modelling in May by Imperial College’s Professor Friston, a world authority in mathematical modelling of complex dynamic biological systems, indicating that around 80% and 50% of the German and UK populations, respectively, are resistant to COVID-19.
T cells target broad range of SARS-CoV-2 epitopes, study shows
According to the scientists, the new research is the most detailed analysis so far of which proteins on SARS-CoV-2 stimulate the strongest responses from the immune system’s “helper” CD4+ T cells and “killer” CD8+ T cells.
“We are now armed with the knowledge of which parts of the virus are recognised by the immune system,” said Professor Alessandro Sette, who co-led the new study.
However, the broad immune response helps and most people have immune cells that can recognise sites other than the receptor binding domain.
Among the epitopes they uncovered, the researchers identified several additional epitopes on the SARS-CoV-2 S protein. By targeting many vulnerable sites on the S protein, the immune system would still be able to fight infection, even if some sites on the virus change due to mutations.
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
An analysis of immune cell responses to SARS-CoV-2 from recovered patients identifies the regions of the virus that is targeted and also reveals cross-reactivity with other common circulating coronaviruses.
-Measuring immunity to SARS-CoV-2 is key for understanding COVID-19 and vaccine development
-Epitope pools detect CD4+ and CD8+ T cells in 100% and 70% of convalescent COVID patients
-T cell responses are focused not only on spike but also on M, N, and other ORFs
-T cell reactivity to SARS-CoV-2 epitopes is also detected in non-exposed individuals
Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic control measures. Using HLA class I and II predicted peptide ‘‘megapools,’’ circulating SARS-CoV-2-specific CD8+ and CD4+ T cells were identified in 70% and 100% of COVID-19 convalescent patients, respectively. CD4+ T cell responses to spike, the main target of most vaccine efforts, were robust and correlated with the magnitude of the antiSARS-CoV-2 IgG and IgA titers. The M, spike, and N proteins each accounted for 11%–27% of the total CD4+ response, with additional responses commonly targeting nsp3, nsp4, ORF3a, and ORF8, among others. For CD8+ T cells, spike and M were recognized, with at least eight SARS-CoV-2 ORFs targeted.
Importantly, we detected SARS-CoV-2-reactive CD4+ T cells in 40%–60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating ‘‘common cold’’ coronaviruses and SARS-CoV-2.
Orthogonal SARS-CoV-2 Serological Assays
NOVEMBER 17, 2020
More recent studies have demonstrated that SARS-CoV-1 neutralizing antibodies can still be detected 12–17 years afterward (Guo et al., 2020; Tan et al., 2020). Given these lessons, conclusions about the rapid loss of immunity to SARS-CoV-2 are premature and inconsistent
SARS-CoV-2 antibodies provide lasting immunity
October 13, 2020
“The latest time-points we tracked in infected individuals were past seven months, so that is the longest period of time we can confirm immunity lasts,” Dr. Bhattacharya said. “That said, we know that people who were infected with the first SARS coronavirus, which is the most similar virus to SARS-CoV-2, are still seeing immunity 17 years after infection. If SARS-CoV-2 is anything like the first one, we expect antibodies to last at least two years, and it would be unlikely for anything much shorter.”
Immunity to COVID-19 is probably higher than tests have shown
A new study from Karolinska Institutet and Karolinska University Hospital shows that many people with mild or asymptomatic COVID-19 demonstrate so-called T-cell-mediated immunity to the new coronavirus, even if they have not tested positively for antibodies.
Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
June 29, 2020
Covid-19 survivors ‘could have long-lasting immunity’
At least six studies have reported T cell reactivity against SARS-CoV-2.
It seemed a truth universally acknowledged that the human population had no pre-existing immunity to SARS-CoV-2, but is that actually the case?
Yet a stream of studies that have documented SARS-CoV-2 reactive T cells in people without exposure to the virus are raising questions about just how new the pandemic virus really is, with many implications.
Not so novel coronavirus?
At least six studies have reported T cell reactivity against SARS-CoV-2 in 20% to 50% of people with no known exposure to the virus.
Understanding the protective value of pre-existing SARS-CoV-2 T cell reactivity “is identical to the situation on vaccines,” said Antonio Bertoletti, professor of infectious disease at Duke-NUS Medical School in Singapore. “Through vaccination we aim to stimulate antibodies and T cell production, and we hope that such induction of immunity will protect … but we need a phase III clinical study to really demonstrate the effect.”
Full article online https://www.bmj.com/content/370/bmj.m3563
ONLINE CHAPTER Immunological methods and applications
The methods and applications described in this chapter will hopefully explain how, in practical terms, one would go about measuring cytokine production by individual T-cell subsets, or antibody production by B-cells, or apoptosis induced by NK cells, and so on.
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Antibodies predating infection
Immunological memory after infection with seasonal human coronaviruses (hCoVs) may potentially contribute to cross-protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Ng et al. report that in a cohort of 350 SARS-CoV-2–uninfected individuals, a small proportion had circulating immunoglobulin G (IgG) antibodies that could cross-react with the S2 subunit of the SARS-CoV-2 spike protein (see the Perspective by Guthmiller and Wilson).
By contrast, COVID-19 patients generated IgA, IgG, and IgM antibodies that recognized both the S1 and S2 subunits. The anti-S2 antibodies from SARS-CoV-2–uninfected patients showed specific neutralizing activity against both SARS-CoV-2 and SARS-CoV-2 S pseudotypes.
A much higher percentage of SARS-CoV-2–uninfected children and adolescents were positive for these antibodies compared with adults.
This pattern may be due to the fact that children and adolescents generally have higher hCoV infection rates and a more diverse antibody repertoire, which may explain the age distribution of COVID-19 susceptibility.
Pfizer Covid-19 vaccine; effectiveness
Reduced BNT162b2 mRNA vaccine response in SARS-CoV-2-naive nursing home residents
The SARS-CoV-2 pandemic impact on nursing home (NH) residents prompted their prioritization for early vaccination.
To fill the data gap for vaccine immunogenicity in NH residents, we examined antibody levels after BNT162b2 mRNA vaccine to spike, receptor binding domain (RBD) and for virus neutralization in 149 NH residents and 111 health care worker controls. SARS-CoV-2-naive
NH residents mount antibody responses with nearly 4-fold lower median neutralization titers and half the anti-spike level compared to SARS-CoV-2-naive healthcare workers.
By contrast, SARS-CoV-2-recovered vaccinated NH residents had neutralization, anti-spike and anti-RBD titers similar to SARS-CoV-2-recovered vaccinated healthcare workers.
NH residents’ blunted antibody responses have important implications regarding the quality and durability of protection afforded by neoantigen vaccines. We urgently need better longitudinal evidence on vaccine effectiveness specific to NH resident populations to inform best practices for NH infection control measures, outbreak prevention and potential indication for a vaccine boost.
Dr. Simone Gold – The truth about the CV19 vaccine
Dr Simone Gold, talking about new experimental mRNA vaccine, safte, effectivens and in the beginning a couple of minutes about her experience with HCQ but most of this video is about the.
what are the concerns regarding the effectiveness:
Super shocking is that there’s no proof that this biological agent actually stops the transmission amongst people!!
I mean it’s like it’s like a joke right, it’s like the punchline to a joke “let’s take a vaccine and by the way it doesn’t actually stop transmission “
And by the way this is not disputed, it’s been well documented that they do not known if it stops transmission
Is it like putting people into sort of an asymptomatic carrier, turning positive and becoming the new positives! People taking the vaccine and now they’re testing positive for COVID-19 is kind of funny!
Are they going to test positive forever!? 10s or hundreds of millions running around just kind of positive; what does that mean? Are they going to tell us that the cases have risen!?
Pfizer Covid-19 vaccine candidate is unimpressive: NNTV is around 256
Pfizer’s vaccine “may be more than 90% effective.” (Mahase, BMJ 2020;371:m4347, November 9)
Specific data are not given but it is easy enough to approximate the numbers involved, based on the 94 cases in a trial that has enrolled about 40,000 subjects: 8 cases in a vaccine group of 20,000 and 86 cases in a placebo group of 20,000.
This yields a Covid-19 attack rate of 0.0004 in the vaccine group and 0.0043 in the placebo group. Relative risk (RR) for vaccination = 0.093, which translates into a “vaccine effectiveness” of 90.7% [100(1-0.093)]. This sounds impressive, but the absolute risk reduction for an individual is only about 0.4% (0.0043-0.0004=0.0039).
The Number Needed To Vaccinate (NNTV) = 256 (1/0.0039), which means that to prevent just 1 Covid-19 case 256 individuals must get the vaccine; the other 255 individuals derive no benefit, but are subject to vaccine adverse effects, whatever they may be and whenever we learn about them
Jan Bonte (Hommel) – the Pfizer / BionTech SARS-CoV-2 virus Vaccin
A fantastic piece from Jan Bonte (Dutch Neurologist) detailing the Pfizer vaccin with all it’s unknowns in respect of efficacy, side- and adverse effects.
Too bad; only a few on this planet master the Dutch language… but with the help of online translators
This link directs you to the original blog …select your language of choice with this link to google translate ; this link to Microsoft web translator
ROADMAP FOR THE IMPLEMENTATION OF ACTIONS BY THE EUROPEAN COMMISSION BASED ON THE COMMISSION COMMUNICATION AND THE COUNCIL RECOMMENDATION ON STRENGTHENING COOPERATION AGAINST VACCINE PREVENTABLE DISEASES
Peter Doshi: Pfizer and Moderna’s “95% effective” vaccines—let’s be cautious and first see the full data
Let’s put this in perspective.
– First, a relative risk reduction is being reported, not absolute risk reduction, which appears to be less than 1%.
– Second, these results refer to the trials’ primary endpoint of covid-19 of essentially any severity, and importantly not the vaccine’s ability to save lives, nor the ability to prevent infection, nor the efficacy in important subgroups (e.g. frail elderly). Those still remain unknown.
– Third, these results reflect a time point relatively soon after vaccination, and we know nothing about vaccine performance at 3, 6, or 12 months, so cannot compare these efficacy numbers against other vaccines like influenza vaccines (which are judged over a season).
– Fourth, children, adolescents, and immunocompromised individuals were largely excluded from the trials, so we still lack any data on these important populations.
Will covid-19 vaccines save lives? Current trials aren’t designed to tell us
The world has bet the farm on vaccines as the solution to the pandemic, but the trials are not focused on answering the questions many might assume they are. Peter Doshi reports
As phase III trials of covid-19 vaccines reach their target enrolments, officials have been trying to project calm. The US coronavirus czar Anthony Fauci and the Food and Drug Administration leadership have offered public assurances that established procedures will be followed. Only a “safe and effective” vaccine will be approved, they say, and nine vaccine manufacturers issued a rare joint statement pledging not to prematurely seek regulatory review.
But what will it mean exactly when a vaccine is declared “effective”? To the public this seems fairly obvious. “The primary goal of a covid-19 vaccine is to keep people from getting very sick and dying,” a National Public Radio broadcast said bluntly.
…Yet the current phase III trials are not actually set up to prove either. None of the trials currently under way are designed to detect a reduction in any serious outcome such as hospital admissions, use of intensive care, or deaths. Nor are the vaccines being studied to determine whether they can interrupt transmission of the virus.
FDA Meeting briefing – Pfizer vaccine details revealed
December 12, 2020
It DOES NOT prevent infection or spread of the disease. Masks & social distancing are still required. Of the 3410 individuals who got infected during the study, almost half were from the vaccinated group. The vaccine did not prevent infection!
Vaccine effectiveness against transmission of SARS-CoV-2
Data are limited to assess the effect of the vaccine against transmission of SARS-CoV-2 from individuals who are infected despite vaccination.
Demonstrated high efficacy against symptomatic COVID-19 may translate to overall prevention of transmission in populations with high enough vaccine uptake, though it is possible that if efficacy against asymptomatic infection were lower than efficacy against symptomatic infection, asymptomatic cases in combination with reduced mask-wearing and social distancing could result in significant continued transmission.
Additional evaluations including data from clinical trials and from vaccine use post-authorization will be needed to assess the effect of the vaccine in preventing virus shedding and transmission, in particular in individuals with asymptomatic infection.
MHRA Public Assessment Report BNT162b2 RNA
MHRA Medicines & Healthcare products Regulatory Agency
Public Assessment Report online Authorisation for Temporary Supply
COVID-19 mRNA Vaccine BNT162b2 (BNT162b2 RNA)
concentrate for solution for injection
Department of Health and Social Care (DHSC)
Pfizer Limited & BioNTech Manufacturing GmbH
The full report online
Section “Serious adverse events“
Two deaths were reported in participants that received BNT162b2 in Phase 2/3 of study
c4591001; narratives were provided. A participant died 3 days after Dose 1; the provisional
cause of death was atherosclerotic disease. A participant experienced cardiac arrest 60 days after Dose 2 and died 3 days later.
Side- and Adverse effects
I have never been critical against any vaccine whatsoever; have had all my vaccinations in the 60’s, some more serving the Dutch navy (1978) and in 2010 another 3 shots for whatever (I forgot what) due to business travel to Saudi Arabia.
Rushing a vaccin with new technology never registered anywhere in the world for a virus with a global iFR 0.15-0.20% (0.03-0.04% in those <70 years) [source John P. A. Ioannidis] to me is utterly madness.
Anyone with a healthy brain should think beyond general statements broadcasted by the main stream media, be critical, questioning the information and do his/her own research.
All online articles are downloadable as a pdf at the end of this paragraph.
Dec 21: Suspicions grow that nanoparticles in Pfizer’s COVID-19 vaccine trigger rare allergic reactions
Severe allergy-like reactions in at least eight people who received the COVID-19 vaccine produced by Pfizer and BioNTech over the past 2 weeks may be due to a compound in the packaging of the messenger RNA (mRNA) that forms the vaccine’s main ingredient, scientists say. A similar mRNA vaccine developed by Moderna, which was authorized for emergency use in the United States on Friday, also contains the compound, polyethylene glycol (PEG). Full article online
Dec 20: CDC Issues New Guidelines, Launches Probe After 1000s Negatively-Affected Following COVID-19 Vaccination.
Thousands of people have been unable to work or perform daily activities, or required care from a healthcare professional, after getting the new COVID-19 vaccine, according to new data from the Centers for Disease Control and Prevention (CDC).
As of Dec. 18, 3,150 people reported what the agency terms “Health Impact Events” after getting vaccinated.
The definition of the term is: “unable to perform normal daily activities, unable to work, required care from doctor or health care professional.” Full article online.
Dec 19: FDA investigating five allergic reactions after Pfizer shot in U.S
Michael Erman NEW YORK (Reuters)
The U.S. Food and Drug Administration is investigating around five allergic reactions that happened after people were administered Pfizer Inc and BioNTech SE’s COVID-19 vaccine in the United States this week, a top FDA official said late on Friday.
Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, said at a press conference that the allergic reactions had been reported in more than one state, including in Alaska
Marks also said that a chemical called polyethylene glycol (PEG) that is an ingredient in the Pfizer vaccine – as well as the Moderna Inc vaccine authorized on Friday – “could be the culprit” causing the reactions.
Marks said that allergic reactions to PEG could be somewhat more common than previously understood. The cases in Alaska were similar to two cases reported last week in Britain.
Britain’s medical regulator has said that anyone with a history of anaphylaxis, or severe allergic reactions to a medicine or food, should not be given the Pfizer-BioNTech COVID-19 vaccine.
But the U.S. Food and Drug Administration has said that most Americans with allergies should be safe to receive the vaccine. It said only people who have previously had severe allergic reactions to vaccines or ingredients in this particular vaccine should avoid getting the shot.
On Friday, the FDA said the Moderna vaccine should not be given to individuals with a known history of a severe allergic reactions to any components of the shot.
The regulator is also requiring that appropriate medical treatments for immediate allergic reactions must be available when the shot is administered in case of an anaphylactic reaction.
Pfizer could not be immediately reached for comment.
Reporting by Michael Erman; Editing by Diane Craft and Daniel Wallis
Dec 16: Alaska healthcare worker with no history of drug allergies suffered serious ‘anaphylactic-like’ reaction
The worker allegedly had no history of allergies to any medication but it’s unknown if he or she had any other allergies.
The allergic reaction is believed to be similar to the anaphylactic-like reactions suffered by two healthcare workers in Great Britain, both whom have since recovered, after they were given the Pfizer-BioNTech SE vaccine.
Dec 12: French Expert Shocked By Number Of Adverse Reactions To COVID-19 Vaccine
“Not only is there a lack of information, but these injections based on genetic material (messenger RNA) have never passed the commercialization stage until now,” Caumes said. “Perhaps they are revolutionary, but I want proof of their reliability, otherwise it is tantamount to placing blind trust in industry.”
Dec 10: As the United Kingdom started inoculating people with the coronavirus vaccine developed by Pfizer-BioNTech, four volunteers who were administered the vaccine in the trial stage developed Bell’s palsy, according to US Food and Drug Administration (FDA) regulators. Bell’s palsy is a form of temporary facial paralysis.
UK Government officials are calling for calm after it emerged that several health workers have suffered an “anaphylactoid reaction” after receiving the Pfizer COVID-19 vaccine.British scientists attempted to quash public panic about the Pfizer/BioNTech following reports that two NHS staff suffered an adverse reaction just after being immunized this week.
Pfizer BioNtech Study: Vaccine has adverse event risks.
One cannot stress how untested this vaccine is. How the FDA would approve this against the known risks of COVID-19, which are very low (under 0.2%), but for a specific population with comorbidity issues that impact them for every flu season (approximately 5%). These people are, in totality, over 55, that have been most impacted (90%+ of U.S. Deaths).
Dec 9: Six people died in Pfizer’s late-stage trial of the COVID-19 vaccine, the US Food and Drug Administration has revealed just hours after Britain became the first country in the world to roll out the vaccine.
BOMBSHELL: More Death and Fever from Pfizer Vaccine than Covid
The FDA briefing document on the Pfizer-BioNTech COVID-19 vaccine contains some stunning information, including the revelation that most people are hundreds of times more likely to have an adverse reaction from their vaccine than they are to die from covid.
On Page 41 of the report, we can see a description of the Serious Adverse Events including 6 deaths and 12 cases of appendicitis. In total 0.6% of participants reported a Serious Adverse Events from the Covid Vaccine – 100 TIMES HIGHER THAN THE PROBABILITY OF DEATH FROM COVID (for under 60’s)
Dec 8: COVID-19 vaccine trial participants said they experienced intense symptoms and warned of possible “adverse effects” as novel coronavirus cases continue to surge across the U.S.
The U.S. Food and Drug Administration released a report Tuesday that said Pfizer and BioNTech’s COVID-19 vaccine candidate is safe and effective against the virus. The FDA also noted that while side effects were common, they have yet to identify the Pfizer vaccine’s safety concerns.
Vaccination card / passport for EU citizens
Covid-19 vaccines: ethical, legal and practical considerations
7.3.1 ensure that citizens are informed that the vaccination is NOT mandatory and that no one is politically, socially, or otherwise pressured to get themselves vaccinated, if they do not wish to do so themselves
Children’s Health Defence
New Analysis: Pfizer Vaccine Killed ‘About 40 Times More Elderly Than the Disease Itself Would Have Killed’
A re-analysis of data from the Israeli Health Ministry concluded Pfizer’s COVID vaccine killed “about 40 times more (elderly) people than the disease itself would have killed” during a recent five-week vaccination period, and 260 times more younger people than would have died from the virus.
While in January a group of independent doctors concluded that experimental COVID-19 vaccines are “not safer” than the virus itself, a new analysis of vaccine-related death rates in Israel demonstrates that this may indeed be the case to dramatic levels.
We Need More Details and the Raw Data
Jan 5, 2021
Peter Doshi: Pfizer and Moderna’s ‘95% Effective’ Vaccines — We Need More Details and the Raw Data
Peter Doshi outlines new concerns about the trustworthiness and meaningfulness of the reported efficacy results of Pfizer’s and Moderna’s COVID-19 vaccine trials.
Flu Vaccine Facts
A compiled list of resources to help you make informed decisions about the flu vaccine in order to protect you and your family from harm.
For instance, mercury (thimerosal) is a neurotoxin and contained in some flu vaccines. It has been linked to neurodevelopmental disorders and many diseases.
CHD Responds to News of Life-Threatening Reaction to Pfizer COVID Vaccine
Polyethylene glycol (PEG) in COVID mRNA vaccines, could cause severe allergic reactions.
CHD’s concerns about PEG stem from the fact that PEG-specific immune responses can actually reduce the efficacy of vaccines and increase the occurrence of adverse events.
RFK, Jr. Warned FDA Three Months Ago About Ingredient in Pfizer COVID Vaccine
Moderna, Pfizer/BioNTech and Arcturus Therapeutics COVID vaccines all utilize a never-before-approved messenger RNA (mRNA) technology, an experimental approach designed to turn the body’s cells into viral protein-making factories. This technology involves the use of lipid nanoparticles (LNPs) that encapsulate the mRNA to protect them from degradation and promote cellular uptake.
The LNP formulations in the three COVID-19 mRNA vaccines are “PEGylated,” meaning that the vaccine nanoparticles are coated with a synthetic, non-degradable and increasingly controversial PEG.
RFK, Jr. Urges FDA to Slow Down COVID Vaccine Approval Process
CHD Asks Journal to Retract Study Saying Flu Vaccines Protect Against COVID
The letter details gross errors in “Considering Interim Interventions to Control COVID-19 Associated Morbidity and Mortality — Perspectives,” an original research paper by Mark Christopher Arokiaraj, published Sept. 22 in Frontiers in Public Health.
After reviewing the paper, Kennedy and Hooker concluded that “because of the nature of the error and the faulty conclusions made from the erroneous results, this paper should be retracted as soon as possible.”
COVID Vaccine Hesitancy Widespread, Even Among Medical Professionals
Seventy-six percent of the vaccine-hesitant healthcare workers cited the “fast-tracked vaccine development” as a primary reason for their concerns. Typically, vaccines take between eight to 10 years to develop, Dr. Emily Erbelding, an infectious disease expert at National Institute of Allergy and Infectious Diseases, told CNN in an article titled, “The timetable for a coronavirus vaccine is 18 months. Experts say that’s risky.”
GSK Recycles Its Problematic Adjuvant into Covid-19 Vaccines
GSK and Sanofi Covid-19 vaccine joint effort.
Under this “unprecedented” arrangement, Sanofi will provide the coronavirus antigen while GSK ponies up its trademark AS03 adjuvant system.
Describing AS03’s mechanisms of action in vaccines, GSK researchers have noted that the adjuvant can induce “rapid perturbation” that activates a response called endoplasmic reticulum (ER) stress. An activated ER stress response has been associated with numerous chronic diseases, and severe ER stress also “threatens proper organ function.” Investigators have described an urgent need to study “the consequences of pharmacological interference with ER stress responses.”
AS03 played out quite differently in Europe, where it featured prominently in GSK’s Pandemrix H1N1 “swine flu” vaccine—widely administered in 2009-2010. The U.S. never licensed Pandemrix. In 2010, after Pandemrix received fast-tracked approval from the European Medicines Agency (EMA) under special rules for declared pandemics, an unusually high number of young people—an estimated 1300 in all—developed severe narcolepsy, “all but wreck[ing] normal life.”
Pentagon Study: Flu Shot Raises Risk of Coronavirus by 36%
On March 12th, 2020, Anderson Cooper and Dr. Sanjay Gupta held a global town hall on “Corona Facts and Fears.” During the discussion, Anderson said to the viewing audience, “And, again, if you are concerned about coronavirus, and you haven’t gotten a flu shot…you should get a flu shot.”
Setting safety and efficacy of influenza vaccination aside, is Anderson’s claim that the flu shot will help people fight COVID-19 remotely true? The short answer is no.
In fact, the results of many peer-reviewed, published studies prove that Anderson’s recommendation may have been the worst advice he could have given the public.
All of the above CHD articles in 1 PDF Binder
SARS-CoV-2 vaccines in development
No vaccines against coronaviruses have yet been licensed for use in humans.
Traditional vaccine development is a lengthy process, and a development time of 15 years is common (Fig. above). The process begins with exploratory work on vaccine design and evaluation in animal models, which can take years.
This is then followed by a stage in which more formal preclinical experiments are conducted, a process for vaccine production is designed and formal toxicology studies are performed; this stage can also last for several years.
Next, an application for an investigational new drug is filed and phase I clinical trials (testing in fewer than 100 individuals; approximately 2 years) are performed to generate an initial safety profile of the vaccine candidate and to obtain preliminary immunogenicity data.
If the results are promising and funding is available, a vaccine candidate is then moved into phase II clinical trials (testing in a few hundred individuals, also lasting about 2 years) to further investigate immunogenicity and to determine an appropriate dose and optimal vaccine regimens.
If the results of phase II trials are encouraging, the decision might be made to move forward with very costly phase III clinical trials (in thousands of individuals; approximately 2 years) in which efficacy and safety are evaluated.
If the outcome of phase III trials meets the pre-defined end points, a biologics license application is filed with regulatory agencies (for example, the United States Food and Drug Administration (FDA) or the European Medicines Agency).
The licensing process can take another 1–2 years, especially if additional data are requested. Importantly, because it is very expensive, the overall process of vaccine development is slowed by economic risk assessment at every step. Vaccine development progresses through these stages only if the developer is convinced that the data are promising, that the risk of failure is relatively low and that there is (still) a market for the vaccine.
– Text below copied from tweet Jan Bonte, Dutch neurologist –
Although vaccine development is moving forward at an unparalleled speed, there are still many open questions. It is likely that two doses of a vaccine will be required, with booster doses potentially necessary at later time points;
in this case, at least 16 billion doses will be needed to meet the global demand. Many of the vaccines that are described below are being developed by entities that have never brought a vaccine to market, or use technologies that have never resulted in a licensed vaccine.
The upper respiratory tract is thought to be mainly protected by secretory IgA, whereas the lower respiratory tract is thought to be mainly protected by IgG. Vaccines that are administered intramuscularly or intradermally induce mainly IgG, and no secretory IgA.
It is therefore possible that most vaccines currently in development induce disease-preventing or disease-attenuating immunity, but not necessarily sterilising immunity.
For SARS-CoV-2 vaccine candidates, there have so far been no signals of enhanced disease in animal models or in humans; however, such a safety signal would certainly derail the development of a vaccine candidate and would negatively affect vaccine development in general.
– Text above copied from tweet. Jan Bonte, Dutch neurologist –
A not to difficult read that gives you a good basic understanding about a “cytokine storm” .
In short, cytokine storm involves an immune response that causes collateral damage, which may be greater than the immediate benefit of the immune response.
This year marks 10 years since the first description of a cytokine storm that developed after chimeric antigen receptor (CAR) T-cell therapy1 and 27 years since the term was first used in the literature to describe the engraftment syndrome of acute graft- versus-host disease after allogeneic hematopoietic stem-cell transplantation.2 The term “cytokine release syndrome” was coined to describe a similar syndrome after infusion of muromonab-CD3 (OKT3).3 Cytokine storm and cytokine release syn- drome are life-threatening systemic inflammatory syndromes involving elevated levels of circulating cytokines and immune-cell hyperactivation that can be triggered by various therapies, pathogens, cancers, autoimmune conditions, and monogenic disorders.
Covid-19 –Associated Cytokine Storm (starting at page 14) .. characterized by heterogeneous symptoms ranging from mild fatigue to life-threatening pneumonia, cytokine storm, and multiorgan failure.
Cytokine storm was also reported in patients with SARS and was associated with poor out comes.
WHO vaccination policies will increase diseases in all populations
Judy Wilyman PhD The WHO recommendations for vaccines are a one-size fits all and this fact means that these policies will increase diseases in all populations. They cannot be described as ‘protective health policies’ because they contradict the science of epigenetics; the science showing that individuals are pre-disposed to diseases due to their genetic make-up and the interaction with chemicals in the vaccines.
Videos to Watch Regarding the False Media Presentation of COVID19
May 25, 2020 By Judy Wilyman PhD
More information on Vaccinationsdecisions.net
Dr Bruce Lipton – Stress, Epigenetics and more
Stress is a Chemical, it causes the blood vessels to shut down.Dr Bruce Lipton
If you understand Epigenetic’s you don’t need the Pharmaceutical Industry.
For those who really want to look beyond the current paradigm of Allopathic medicine / allopathy.
The full interview at LondonReal
Dr Bruce Lipton https://www.brucelipton.com
B.A. in biology from C.W. Post Campus of Long Island University in 1966.
PhD in developmental biology from the University of Virginia in 1971.
1973 to 1982 Taught anatomy at the University of Wisconsin School of Medicine, before joining St. George’s University School of Medicine as a professor of anatomy for three years
Epigenetics is the study of heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence — a change in phenotype without a change in genotype — which in turn affects how cells read the genes. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle, and disease state. Epigenetic modifications can manifest as commonly as the manner in which cells terminally differentiate to end up as skin cells, liver cells, brain cells, etc. Or, epigenetic change can have more damaging effects that can result in diseases like cancer. At least three systems including DNA methylation, histone modification and non-coding RNA (ncRNA)-associated gene silencing are currently considered to initiate and sustain epigenetic change.1 New and ongoing research is continuously uncovering the role of epigenetics in a variety of human disorders and fatal diseases. Epigenetics Fundamentals
Epigenetics explained in simple terms (3 minutes)
Dr. Eric Berg, DC
Young doctor explains why he’s against forced COVID-19 vaccine
A COVID-19 vaccine should not be mandatory, and getting people to take it “serves certain special interests,” a young medical doctor told LifeSiteNews.
“I have no doubt about it,” Dr. Leland Stillman said when LifeSite’s video reporter Jim Hale asked him if the push for the vaccine had, in many ways, to do with money. Hale spoke with Stillman at the “March Against Mandates” in Richmond, Virginia, last week.
National Childhood Vaccine Injury Act of 1986 – The Legislation that Changed Everything
eBook Conflicts of Interest Undermine Children’s Health
SAGE conflicts of interest
WHO Strategic Advisory Group of Experts (SAGE)
November 9, 2020
* As late as March 11th, 2020, the UK government and medical officers issued practical and minimally disruptive advice to combat the spread of the novel coronavirus.
* On March 16th, the now infamous Neil Ferguson/Imperial College paper was published predicting over 500,000 deaths in the UK and 2.2 million in the US if suppression measures were not introduced.
* Stricter measures were announced on the day that paper was published, and the first UK lockdown was announced a week later, on March 23rd. US states variously followed suit.
* The committee that has been advising the government throughout this period is called the Scientific Advisory Group for Emergencies (SAGE). Ferguson was a member of this committee until he resigned in May for having broken lockdown rules.
* This week’s note examines the key influencers on SAGE and their conflicts of interest:
– Organisations invested in vaccines make money from vaccines. People who acquire natural immunity have less/no need for a vaccine. If people are locked in their homes, they have less chance of acquiring natural immunity.
– Twelve out of 20 key influencers work for/have received funding from organisations involved in the Covid-19 vaccine.
– There are four times more modellers/statisticians and experts in behaviour manipulation on the committee than there are virologists. There are no immunologists.
* It doesn’t matter if a drug is good or bad. It matters that those who have a financial interest in that drug are conflicted if they give advice that protects the financial interest in that drug.
MD Stanley Plotkin speaks under oath about vaccine ingredients.
Dr. Stanley Plotkin considered one of the leading experts on vaccines and vaccinations.
In the 1960s, he played a critical role in the development of the rubella vaccine and several manufacturers ask him for his advice.
And if you have 9 hours to spare the full version:
Aborted fetal tissues are used in vaccines. Vaccines have been experimentally tested on orphans and on mental handicapped children. Experimental tests on babies from mothers in prisons. Experimental tests on 1 million people in then colonial Belgian Congo. Shocking video.
Dr. Carrie Madej – My alarm call to the world
Internal Medicine Specialist in McDonough, GA Graduated from Kansas City Univ Of Medicine Bioscience College Of Osteopathic Medicine medical school in 2001. Affiliated with medical facilities Piedmont Fayette Hospital and Southern Regional Medical Center.
RNA vaccines, classes of vaccine that has never been approved for human use in the U.S. and involve injecting foreign genetic material into the human body. Notably, it is this very class of vaccine, now being produced by DARPA-partnered companies, that billionaire and global health “philanthropist” Bill Gates recently asserted has him “most excited” relative to other Covid-19 vaccine candidates. Yet, key aspects regarding these vaccines and other DARPA “healthcare” initiatives have been left out of these recent positive reports.
Watch this highly informative video by physician Dr. Carrie Madej, explaining the 3 major components of the Moderna vaccine and the implications.
If we allow the mandatory vaccination rhetoric to proceed , humans will no longer be human. Dr. Madej does an outstanding job going into greater detail. Remember, the function of RNA is to repair and re-write the DNA.
Another great article on this subject:
FDA Nears Approval of Injectable Biochip Implants for COVID Detection
The Department of Defense, and the Bill and Melinda Gates Foundation, have partnered with a Silicon Valley company, Profusa, to implement a technology which could control our minds and bodies. What may seem like science fiction, is in fact happening in real-time.
A permanent chip made of an advanced material called hydrogel irreversibly ties humans to the Internet “cloud.” The chip, about the size of a grain of rice, provides feedback to a database on changes in body chemistry and other biometrics. The company says technology will be used to detect COVID in the general population, before symptoms show.
The latest revised CDC overall survival rate for the COVID virus is 99.8%, versus 99.9% for the common flu. Nevertheless, nearly 150 days after governments proclaimed that 15 days of “lockdowns” and social distancing would be necessary to “flatten the curve” so that hospitals would not be overwhelmed, US governors still exert emergency powers based on the announcement of “new cases.”
Full article: https://steemit.com/covid/@munkle/permanent-injectable-biochip-covid-sensors-near-fda-approval Reader view backup:
Robert F Kennedy Jr. at Londonreal.tv
My fight agains mandatory vaccinations, big pharma and Dr. Fauci
Children’s Health Defense; Measles Vaccination and Autism
In a surprisingly candid systematic review of the autoantibody literature just published in Research in Autism Spectrum Disorders, authors from Harvard and other American universities cite long-standing evidence that viral vaccines—and explicitly the MMR—are one of the culprits capable of knocking the immune system off its game.
Instagram video July 7, 2020 Robert f Kennedy; discussion with Dr. Andy Lakefied
Influenza vaccination and respiratory virus interference
Vaccinated individuals may be at increased risk for other respiratory viruses because they do not receive the non-specific immunity associated with natural infection.
Additionally, the laboratory data in our study showed increased odds of coronavirus and human metapneumovirus in individuals receiving influenza vaccination.
The overall results of the study showed little to no evidence supporting the association of virus interference and influenza vaccination.
Does the Flu Shot Increase COVID-19 Risk (YES!)
Dr. Michael Murray This may be the most important newsletter I have written to date. Here are a few quick answers to the questions I will cover in case you aren’t interested in the whole story:
- Does the flu shot increase the risk for coronavirus infection? YES!
- Could a new flu vaccine be partly responsible for the COVID-19 mortality rate in Italy? YES!
- Is the rush to a vaccine the best solution? No, it could bring catastrophic results.
- How does the SARS-CoV-2 infect and are protease enzyme supplements the key to creating our own endogenous antiviral protease inhibitors? Yes, I believe so!
- Are there certain medications like blood pressure drugs and proton pump inhibitors that increase risk for infection and mortality? YES
- Is it chloroquine or is it zinc that is working as a possible aid in treating COVID-19? A strong case can be made for zinc!
- Can plant polyphenols and flavonoids act to increase the antiviral effects of zinc? YES! And they possess other benefits too!
Flu shots contain suspect ingredients, carcinogen formaldehyde, mercury in the form of thimerosal.
“Mercury is one of the most poisonous substances known to mankind,” Dr. Brownstein tells Newsmax Health. “It is a potent neurotoxin and is associated with a host of neurological and immune system problems. Mercury should never be injected into any living human being.”
Thimerosal, a preservative found in many flu shots, is 50 percent mercury. It’s different, and much more harmful, than the type of mercury found in fish. While the FDA warns against eating more than two servings of fish weekly because of the danger of mercury, it allows this more toxic form to be added to flu shots (and other vaccines).
“There’s no doubt that the flu vaccine can lead to Alzheimer’s, because many flu shots are preserved with mercury and it’s a known brain toxin,” says Dr. Brownstein. “You give enough brain toxins and people are going to develop memory issues.”
“Those promoting flu shots promise they’ll cut your risk of getting flu by more than 50 percent, but that’s simply not true. When you dissect the studies, you’ll find the FluLaval vaccine is 97 percent ineffective.”
Full article https://www.newsmax.com/Health/Headline/flu-shots-vaccine-thimerosal/2014/11/20/id/608614/
Past vaccine disasters show why rushing would be ‘colossally stupid’
CNN Health’s Jamie Gumbrecht contributed to this story
Vaccine experts are warning the federal government against rushing out a coronavirus vaccine before testing has shown it’s both safe and effective. Decades of history show why they’re right.
https://edition.cnn.com/2020/09/01/health/eua-coronavirus-vaccine-history/index.html Reader view backup for download:
Mandatory Vaccination consider this
The issues raised by the Nuremberg trials are as relevant to medicine in 1996 (and 2020) as in 1946
The Nuremberg trials of doctors who had committed war crimes during the second world war began 50 years ago this week.
The BMJ has devoted many pages in this issue to exploring the Nuremberg trials, what went before, and their aftermath for two main reasons.
Firstly, we must never forget. On the wall of the highly moving United States Holocaust Museum is a quote from Deuteronomy: “Only guard yourself and your soul carefully, lest you forget the things your eyes saw.”
Secondly, the issues thrown up by the trials–informed consent for experimentation, the involvement of doctors with the state, patient autonomy, genocide, and the behaviour of doctors when associated with abuses of human rights–are as relevant today as the day the trials began.
Indeed, there is a sense, particularly in Germany, that we are at the very beginning of thinking through the issues thrown up by what doctors did in the second world war.
We needed 50 years to be able to begin to think clearly about something so horrible.
– the whole story via this link or download my pdf backup below.
1. Any preventive, diagnostic and therapeutic medical intervention is only to be carried out with the prior, free and informed consent of the person concerned, based on adequate information. The consent should, where appropriate, be express and may be withdrawn by the person concerned at any time and for any reason without disadvantage or prejudice.
2. Scientific research should only be carried out with the prior, free, express and informed consent of the person concerned. The information should be adequate, provided in a comprehensible form and should include modalities for withdrawal of consent. Consent may be withdrawn by the person concerned at any time and for any reason without any disadvantage or prejudice. Exceptions to this principle should be made only in accordance with ethical and legal standards adopted by States, consistent with the principles and provisions set out in this Declaration, in particular in Article 27, and international human rights law.
3. In appropriate cases of research carried out on a group of persons or a community, additional agreement of the legal representatives of the group or community concerned may be sought. In no case should a collective community agreement or the consent of a community leader or other authority substitute for an individual’s informed consent.
The ten points of the Nuremberg Code
- Voluntary consent is essential
- The results of any experiment must be for the greater good of society
- Human experiments should be based on previous animal experimentation
- Experiments should be conducted by avoiding physical/mental suffering and injury
- No experiments should be conducted if it is believed to cause death/disability
- The risks should never exceed the benefits
- Adequate facilities should be used to protect subjects
- Experiments should be conducted only by qualified scientists
- Subjects should be able to end their participation at any time
- The scientist in charge must be prepared to terminate the experiment when injury, disability, or death is likely to occur
ETHICAL PRINCIPLES FOR MEDICAL RESEARCH INVOLVING HUMAN SUBJECTS.
The World Medical Association (WMA) has developed the Declaration of Helsinki as a statement of ethical principles for medical research involving human subjects, including research on identifiable human material and data.
Council of Europe
Convention for the protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine: https://www.coe.int/en/web/conventions/full-list/-/conventions/treaty/164
Chapter II – Consent
Article 5 – General rule
An intervention in the health field may only be carried out after the person concerned has given free and informed consent to it.
This person shall beforehand be given appropriate information as to the purpose and nature of the intervention as well as on its consequences and risks.
The person concerned may freely withdraw consent at any time.
This Declaration addresses ethical issues related to medicine, life sciences and associated technologies as applied to human beings.
NIH National Library of Medicine
The Convention on Human Rights and Biomedicine developed by the Council of Europe, now undergoing ratification, is the first international treaty focused on bioethics. This article describes the background of the Convention’s development and its general provisions and provides a comparison of its requirements with those of federal regulations governing research with human subjects. Although most provisions are comparable, there are significant differences in scope and applicability, for example, in the areas of compensation for injury, research participation by persons with limited capacity to consent, assisted reproduction, organ transplantation, and research in emergency situations. The Convention represents a milestone in international bioethics and protection of human rights that will probably be referred to with increasing frequency
United Nations Educational, Scientific and Cultural Organization
The Biderman Report of 1956 and Covid-19
‘The truth, when you finally chase it down is almost always far worse than your darkest visions and fears.’— Hunter S. Thompson
In 1956, there was a study of the impacts of trauma-based mind control on Korean War prisoners detained by communists in North Korea and China. It was call the Biderman Report. Another document followed in 1961. What follows are observations from those documents.
The fear of being controlled by others, with the consequent loss of the autonomy, is believed to be fundamental to the conception of the self and the will.
Communist Coercive methods for eliciting individual compliance
Biderman’s Chart of Coercion
A tool designed to demonstrate and explain the coercive methods of stress manipulation used to torture prisoners of war. It has been applied to explain the coercive techniques used by perpetrators of domestic abuse.
This list directly reflects the original chart, it has not been changed to fit the domestic abuse context. Biderman Report
A parent doctor discussion on Immunization / Vaccination
Doctor: Is your child immunized?
Doctor: It’s not in his records.
Me: Why would it be?
Doctor: What do you mean?
Me: What do you mean?
Doctor: Who immunized your child?
Me: My wife and I.
Doctor: What do you mean?
Me: What do you mean?
Doctor: How did you and your wife immunize your child?
Me: She birthed him naturally at home and breastfed him for the first year and a half of his life, and we both make sure he eats nutritionally dense organic foods. We also make sure he spends a lot of time in the sun moving his body daily out in nature connected to the earth, and pretty much only drinks water that comes straight from a natural spring without any fluoride or chlorine in it.
Doctor: But I asked you if your child has been vaccinated, and you said “yes!”
Me: No, you asked me if my child has been immunized, and I said “yes.”
Doctor: Vaccinations…immunizations…same thing!
Me: Uhhh…you keep using that word, but I don’t think you know what it means…
Doctor: What do you mean?
Me: What do you mean?
Doctor: (visibly frustrated) Never mind. Are you going to have him vaccinated or not?
Me: Why would I?
Doctor: So he doesn’t get sick.
Me: But he doesn’t get sick now.
Me: Not really, ….
DNA vs. RNA – 5 Key Differences and Comparison
Deoxyribonucleic acid (DNA) and Ribonucleic acid (RNA) are perhaps the most important molecules in cell biology, responsible for the storage and reading of genetic information that underpins all life. They are both linear polymers, consisting of sugars, phosphates and bases, but there are some key differences which separate the two.
COVID19 is a Pandemic of fear, fleeing in logic in which we restrict reality, resulting in destroying society and at the same time creating dangerous social mechanisms.