vaccination during a pandemic

Why should current Covid-19 vaccines not be used for mass vaccination during a pandemic?

Dr G. Vanden Bossche, DVM, PhD -Independent Vaccine Research Consultant

Dear colleagues at the WHO, my name is Geert Vanden Bossche (GvdB). 

My background is veterinary medicine. I’m a certified expert in microbiology and infectious diseases. I have a PhD in Virology and I have a long-standing career in human vaccinology. 

I’m urging you to immediately open the scientific debate on how human interventions in the COVID-19 pandemic are currently driving viral immune escape. 

I’m urging you to invite me for a scientific hearing open to the public and to scientists all over the world on this very topic. Ignoring or denying the impact of stringent infection prevention measures combined with mass vaccination using prophylactic vaccines is a colossal blunder. 

Please do listen to my cry of distress and let’s first and foremost deliberate, on a scientifically justified strategy. To mitigate the tsunami of morbidity and lethality that is now threatening us. 

And let’s meanwhile derive a strategy to eradicate the steadily emerging highly infectious variants. On behalf of humanity, I sincerely thank you for considering my call.

Dr G. Vanden Bossche, DVM, PhD -Independent Vaccine Research Consultant
Vaccines Summit Ohio 2021, March 1-3, 2021, Ohio, USA Presentation Dr G. Vanden Bossche

GvdB Sharing his perspective on mass vaccination in COVID-19

Geert Vanden Bossche PhD, an internationally recognised vaccine developer having worked as the head of the Vaccine Development Office at the German Centre for Infection Research.

Coordinated Global Alliance for Vaccines and Immunisation’s Ebola Vaccine Program and contributed to the implementation of an integrated vaccine work plan in collaboration with Global Health Partners (WHO, Bill & Melinda Gates Foundation, CDC, UNICEF), regulators (FDA) and vaccine manufacturers to enable timely deployment or stockpiling of Ebola vaccine candidates.

Highlighting the principle of using a prophylactic vaccine in the midst of a pandemic. Likely to create more more viral variants in the process. Sharing his perspective on mass vaccination in COVID-19.

Deep Dive Questions and Answers with GvdB and Dr Philip McMillan
Website Geert Vanden Bossche

Dr Vernon Coleman – March 13, 2021

Now more than ever, I need your help. Unless we work together, we are doomed.

I need your help because we need to reach millions with this video and with the big platforms and the mainstream media having banned me, I can’t reach those millions without you. I believe this is the most important video. I will ever make and the most important you will ever see.

I fear that the genocidal lunatics, the horsemen of the Apocalypse who planned this fraud are leading us into Armageddon.

Millions have received one of the COVID-19 vaccines may die as a result of those vaccinations.  But the politicians and the advisers did everything wrong. And those who questioned what was happening were demonised and silenced.

The public were originally assured that only through a huge vaccination program could they possibly win back some of their last freedoms. This was always dangerous nonsense.

The 1st problem is that these experimental vaccines have already proved to be desperately dangerous, killing many people already and producing serious adverse events in many more. The size of this particular problem can be judged by the fact that even the authorities admit that probably only one in 100 vaccine related deaths and serious injuries will be reported. It’s impossible to estimate how many will die of allergy problems, heart trouble, strokes, neurological problems, and so on. Or how many would be blinded or paralysed?

The 2nd problem is the immune system problem, known as pathogenic priming or cytokine storm. What happens is that the immune system of the person who’s been vaccinated will be primed to respond in a very dramatic way If that individual comes into contact with the virus in the future.

The result can be catastrophic, and this is what I fear will happen in the autumn and during next winter. The people who’ve had the vaccine are going to be in real trouble when they next come into contact with the coronavirus. Their immune systems will overreact, and that’s likely to be when they will be lots of deaths.

Patients haven’t been officially warned about this problem, although the evidence was published in the International Journal of Clinical Practice for October last year. The paper entitled Informed Consent Disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease. But there’s been no informed consent for patients, and I suspect that most doctors remain ignorant of the risks.

Patients are being told that there are no dangers with these vaccines. The elderly and those with poor immune systems are particularly likely to be killed.

The coronavirus spreads most rapidly in autumn and winter. As a result of the epidemic of illnesses and deaths that will take place, governments will start promoting the next round of vaccinations. There will be much talk of mutations and new horridly prepared experimental vaccines will be produced and heavily promoted.

And this brings us to the 3rd problem, a problem. I don’t think they expected. This problem is just being outlined by Dr Geert Vanden Bossche, who’s a very eminent vaccine specialist. Indeed, I was originally skeptical about what he said because Dr Vanden Bossche has previously worked with Gavin, the Gates Foundation. He’s the last person in the world who could be described as being opposed to vaccination. He pointed out that the vaccines which are currently being used are the wrong weapons to use for this war against the virus infection. Disastrously by giving vaccines to millions, teaching the virus, how to mutate and to become stronger and more deadly.

Trying to devise new vaccines for new mutations simply makes things worse because the scientists can’t possibly get ahead of the mutated viruses and the people who have been vaccinated and now sharing mutated viruses with those around them from the mutations are becoming stronger and deadlier. Ending the lockdowns will be perfectly timed to ensure that new mutations of the COVID-19 virus are spread far and wide.

There’s another associated problem too. Normally our bodies contain white blood cells, which help us defeat infections cells called NK cells. Once the NK cells have done their work our antibodies appear and clean up the mess.

However, Dr Vanden Bossche explains that the COVID-19 vaccines are triggering the production of very specific antibodies which compete with the natural defences of the individuals who’ve had the vaccines.

The Natural defence systems of those who been vaccinated are being suppressed because the specific antibodies which have been produced by the vaccine just take over, and these specific antibodies, the ones produced by the vaccines, are permanent there forever within the bodies of the people who had been vaccinated.

The disastrous result is that the natural immune systems of the 10s or hundreds of millions who are having the vaccines are being effectively destroyed.

Their immune systems will not be able to fight any mutated variation of the virus which develops within their bodies.

And those mutated viruses can spread out into the community. I believe This is why new virus variations are appearing in areas where the vaccine has been given to lots of people.

The bottom line is that giving the vaccines will give the virus an opportunity to become infinitely more dangerous. Every vaccinated individual has the potential to become a mass murderer because their bodies are becoming laboratories, making lethal viruses and worse still, some of the vaccinated individuals may become asymptomatic carriers, spreading lethal viruses around them.

The people who’ve had the vaccine won’t be able to respond to the mutations because their immune systems have been taken over by an artificial defence system given to them by the vaccine. Undesigned to combat the original form of the COVID-19 virus. The vaccinated individuals are going to be very much at risk when the new mutations start to spread.

Giving new vaccines won’t help because the mutated virus will not be vulnerable. The scientists who are making vaccines won’t be able to get ahead of the mutating virus.

If Dr Vanden Bossche is right and I believe he is, then it’s the vaccinated individuals who are going to threaten mankind. They’ll be a major threat to anyone who’s been vaccinated. But they’ll also be a major threat to the under vaccinated because the viruses there shedding are going to be more dangerous than the original one.

We are in very dangerous territory if we don’t stop this vaccine program now, then it’s no exaggeration to say that the very future of mankind is at risk.

Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals

Apprehension exists that variants of concern (VOCs) may evade vaccine protection, due to evidence of reduced neutralization of the VOCs B.1.1.7 and B.1.351 by vaccine sera in laboratory assays.

SARS-CoV-2 immunity-escape variants, 7 January 2021

Paper prepared by academics for NERVTAG on viral evasion during antibody treatment of the new SARS-CoV 2 immunity-escape variants. It was considered at SAGE 75 on 7 January 2021.

  1. Concerns have been raised about the possible emergence of SARS-CoV-2 variants that escape immune recognition because of:
    1. The recent identification of two SARS-CoV-2 variants (one in the UK and the other in South Africa) with apparently increased transmission and substitutions in the receptor binding domain (RBD) on the spike protein that theoretically might be associated with immune escape;
    2. High levels of SARS-CoV-2 incidence in the community in the UK associated with a variant B.1.1.7;
    3. The decision in the UK to provide the second dose of SARS-CoV-2 vaccine at 12 weeks rather than 3 weeks after the first dose.
  2. This paper explores the possibility that SARS-CoV-2 escape variants that are partially or fully resistant to natural immunity, vaccination or antibody therapies may have arisen or will arise.

Particularly in immune suppressed individuals with prolonged viral replication, viral evasion can occur during antibody-based treatment. However, the overall impact of these escape variants on clinical and virological outcomes are not clear.

Circulating SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. 

Cross-neutralization of B.1.351 variants was weak and comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses.

While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizing humoral immunity and emphasize the need to develop broadly protective interventions against the evolving pandemic.

In summary, our data highlights the challenges facing all vaccines whose designs were finalized early in the pandemic and based on the sequence of the first-reported virus from Wuhan, China.

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Numerous variants of SARS-CoV-2-harboring mutations in spike have arisen globally
mRNA vaccines elicit potent neutralizing activity against homologous pseudovirus
Cross-neutralization of strains with receptor-binding domain (RBD) mutations is poor
Both RBD and non-RBD mutations mediate escape from vaccine-induced humoral immunity

Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2. Five of the 10 pseudoviruses, harboring receptor-binding domain mutations, including K417N/T, E484K, and N501Y, were highly resistant to neutralization. Cross-neutralization of B.1.351 variants was comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses. While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizing humoral immunity and emphasize the need to develop broadly protective interventions against the evolving pandemic.

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

B.1.1.7, B.1.351 and P.1 do not show augmented host cell entry
Entry inhibitors under clinical evaluation block all variants
B.1.351 and P.1 can escape from therapeutic antibodies
B.1.351 and P.1 evade antibodies induced by infection and vaccination

The global spread of SARS-CoV-2/COVID-19 is devastating health systems and economies worldwide. Recombinant or vaccine-induced neutralizing antibodies are used to combat the COVID-19 pandemic. However, the recently emerged SARS-CoV-2 variants B.1.1.7 (UK), B.1.351 (South Africa) and P.1 (Brazil) harbor mutations in the viral spike (S) protein that may alter virus-host cell interactions and confer resistance to inhibitors and antibodies. Here, using pseudoparticles, we show that entry of all variants into human cells is susceptible to blockade by the entry inhibitors soluble ACE2, Camostat, EK-1 and EK-1-C4. In contrast, entry of the B.1.351 and P.1 variant was partially (Casirivimab) or fully (Bamlanivimab) resistant to antibodies used for COVID-19 treatment. Moreover, entry of these variants was less efficiently inhibited by plasma from convalescent COVID-19 patients and sera from BNT162b2 vaccinated individuals. These results suggest that SARS-CoV-2 may escape neutralizing antibody responses, which has important implications for efforts to contain the pandemic.

mRNA Vaccine Induced Damage mechanisms

Dr. Loretta Bolgan
The various mechanisms by which COVID-19 vcaccines can induce immunopathologies.

Sars-Cov-2, could certinaly be responsible for the phenomenon of disease enhancement in vaccinees, which should have been investigated and excluded before proceeding with human trials.

Given the similarity between the mechanisms of COVID-19 damage and vaccine adverse reactions, it is conceivable that many of the symptoms and pathologies associated with long-COVID may also be present as long-term consequences of vaccination.

Long read -34 pages: Original italian language English version